Mescaline

• feelings of interconnectedness,
• spiritual events,
• euphoriafeelings of joy and happiness,
• increased sensitivity to touch,
• increased sense of smell,
• music enhancement,
• increased persistence of vision ⁴.

• nausea,
• vomiting,
• unwanted spiritual experiences,
• tension,
• anxiety,
• intense feelings of dread and doom ⁴.

• oral – 45 – 120 minutes ⁵.
• all ROA’sroute of administration - where the drug gets into your body – 60 – 180+ minutes ⁶.

• oral – 4 – 6 hours ⁵.

• all ROA’sroute of administration - where the drug gets into your body – 6 – 12 hours ⁶.

• oral – 4 – 12 hours ⁵.
• all ROA’sroute of administration - where the drug gets into your body – 3 – 5 hours ⁶.

The LD50the amount of a material, given all at once, which causes the death of 50% (one half) of a group of test animals. The LD50 is one way to measure the short-term poisoning potential (acute toxicity) of a material is unknown in humans. In experiments with rats, the LD50the amount of a material, given all at once, which causes the death of 50% (one half) of a group of test animals. The LD50 is one way to measure the short-term poisoning potential (acute toxicity) of a material for mescaline has been established in the range of 800 – 1,200mg/kg orally. Considering the human dose range is about 100 – 1000mg, it would be very difficult to consume enough mescaline to kill a human. As such, there are no recorded human deaths from the ingestion of mescaline. With that said, caution is still advised when consuming high doses ⁴.

The toxicityThis is when too much of something is taken over a short period of time More and long-term health effects of recreational mescaline use do not seem to have been studied in any scientific context and the exact toxiccapable of causing injury or death dose is unknown. This is because the lethal dosage for humans has not been formally studied and there are no known fatal over doses within the literature. Anecdotal evidence from people within the psychonaut community who have tried mescaline suggests that there are no negative health effects attributed to simply trying the drug by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed) ⁵.

• full tolerancethis is the process by which the receptors in your brain become habituated to the action of a drug. When tolerance is reached, more of the drug is required to achieve the same effect. With benzodiazepines, and probably with many other classes of drugs as well, tolerance is virtually always associated with some degree of physical dependence. If you find that you are experiencing tolerance, this is a clear warning sign that you may have formed a dependence. More is reached almost immediately after ingestion,
• decreases to half after 3 days,
• returns to baseline after 7 days,
• cross-tolerance with all psychedelics ⁵.

• nausea,
• altered states of perception/feeling,
• increased body temperature,
• increased heart rate,
• increased blood pressure,
• loss of appetite,
• sleeplessness,
• numbness,
• weakness,
• tremors,
• terrifying thoughts,
• anxiety,
• fear of insanity,
• fear of depth,
• fear of losing control ¹³.

• flashbacks,
• hallucinogen persisting perception disorder ¹³,
• paranoiasuspicion, distrust or fear of other people,
• mood disturbances,
• visual disturbances,
• disorganised thinking ¹⁴.

• illusions,
• hallucinationswhere someone sees, hears, smells, tastes or feels things that don't exist outside of their mind,
• altered perception of space and time,
• altered body image ²,
• vivid mental images,
• distorted vision,
• synaesthesiaa condition in which normally separate senses are fused, in which one type of stimulation evokes the sensation of another, as when the hearing of a sound produces the visualisation of a colour More,
• joy,
• exhilaration,
• panic,
• extreme anxiety,
• terror,
• distorted sense of body (users can feel either weighed down or weightless),
• heightened sensory experiences (i.e. brighter colors, sharper visual definition, increased hearing acuity, more distinguished taste),
• difficult focusing,
  • maintaining attention,
  • concentrating,
  • thinking,
• loss of sense of reality – melding past experiences with present,
• preoccupation with trivial thoughts, experiences, or objects,
• highly adverse reactions (“bad trip”), including –
  • frightening hallucinationswhere someone sees, hears, smells, tastes or feels things that don't exist outside of their mind,
  • confusiontrouble focusing, slow or disorganised thinking, poor short-term memory, unsure of time or place, or having difficulty following a conversation,
  • disorientation,
  • paranoiasuspicion, distrust or fear of other people,
  • agitation,
  • depression,
  • panic, and/or
  • terror ⁸,
• conceptual thinking,
• delusions,
• thought loops,
• time distortion,
• analysis enhancementbest described as a subtle to distinct enhancement of one's overall ability to process information and logically or creatively analyse concepts, ideas and scenarios. The experience of this leads onto deep and complex states of contemplation which often result in an abundance of new and insightful ideas. This gives the person a powerful ability to dissect and rationally analyse concepts and problems, allowing them to gain insights and reach new conclusions, perspectives and solutions which would have been otherwise difficult to conceive of. More,
• creativity enhancement,
• emotion enhancement,
• immersion enhancementThis is an effect which can be described as a pronounced increase in one's ability to become fully engulfed within external visual or auditory stimuli such as music, movies, video games and various other forms of media. More,
• increased music appreciation,
• novelty enhancement,
• personal meaning enhancement,
• suggestibility enhancementcan be described as an increase in one's quality of being inclined to accept and act on the suggestions of others. More,
• thought acceleration,
• wakefulness,
• memory suppression,
• personal bias suppression,
• existential self-realisation,
• feelings of interdependent opposites,
• spirituality enhancement,
• unity and interconnectedness ⁵.

• synaesthesiaa condition in which normally separate senses are fused, in which one type of stimulation evokes the sensation of another, as when the hearing of a sound produces the visualisation of a colour More ⁵.

• intense nausea,
• vomiting,
• dilation of the pupils,
• increased heart rate,
• increased blood pressure,
• rise in body temperature,
• heavy perspiration,
• headaches,
• muscle weakness,
• impaired motor coordination ²,
• numbness,
• tension,
• anxiety,
• rapid reflexes,
• muscle twitches,
• impaired motor coordination,
• dizziness,
• trembling,
• appetite suppression,
• sweating,
• chills,
• shivering ⁸,
• physical euphoriaan intense feeling of pleasure and well-being More,
• spontaneous tactile sensationsthese can be described as the physical experience of an activation of nerve endings across the body occurring without any obvious or immediate physical trigger. The experience of this results in feelings of distinct random tactile input and general tingling sensations. Depending on the psychoactive substance consumed, these vary greatly in their alternative styles of sensation, but can be broken down into three basic levels of intensity. These are described and listed here - 1. Mild - The lowest level of the sensation can be described as light and fleeting tingling sensations across the body that do not impair physical motor control and can essentially be ignored if one wishes to do so, and - 2. Distinct - At this level, the sensation becomes impossible to ignore. It can be described as distinct tingling sensations which are intense enough to partially impair a person’s motor control and cause a significant portion of mental focus to be directed towards these sensations, and - 3. Overwhelming - The highest level occurs when the tingling sensations have increased enough to become a powerful, uncontrollable focus point of attention. This feels completely overwhelming and impairs a person's motor control, consistently leaving them either lying or sitting down, incapable of standing up, or writhing in the all-encompassing sensations More,
• bodily control enhancement,
• stimulationcan be defined as any changes in a person's energy levels which are interpreted as stimulating and encouraging when it comes to movement and physical activities such as running, walking, cleaning, socializing, dancing, and climbing More,
• tactile enhancement ⁵,
• dry mouth,
• flushed skin,
• increased energy levels,
• loss of appetite,
• sleep difficulties ¹⁵.

• colour enhancement,
• pattern recognition enhancement,
• visual acuity enhancement,
• after images,
• colour shifting,
• drifting – (melting, flowing, breathing and morphing) – In comparison to other psychedelics, this effect can be described as highly detailed, slow and smooth in motion, static in appearance and realistic in style,
• scenery slicingbest described as an effect which only occurs spontaneously and rarely sustains itself for more than several seconds. The experience of this effect splits the visual field into separate sections. These individual slices then proceed to drift slowly away from their original position before disappearing and resetting to normality. More,
• symmetrical texture repetition,
• tracers ⁵,
• autonomous entities,
• internal hallucinationsbest described as the perception of imagery and scenes which are experienced exclusively within a layer in front of one's open or closed eye vision and not seamlessly within the external environment around oneself. At lower levels, internal hallucinations begin with imagery which does not take up the entirety of one's visual field and is distinctively separate from its background. These can be described as spontaneous moving or still images of scenes, concepts, places, and anything one could imagine. They are manifested in varying levels of detail, ranging from ill-defined and cartoon-like in nature to completely realistic and beyond realism through seemingly impossible, non-euclidean geometric forms. They rarely hold their form for more than a few seconds before fading or shifting into another image. More,
• perspective alterations,
• transformations ⁵.

• auditory distortion,
• auditory enhancement,
• auditory hallucinationswhere someone sees, hears, smells, tastes or feels things that don't exist outside of their mind ⁵.

• feelings of interconnectedness,
• spiritual events,
• euphoriafeelings of joy and happiness,
• increased sensitivity to touch,
• increased sense of smell,
• music enhancement,
• increased persistence of vision ⁴.

• altered thinking processes,
• an altered sense of time and self-awareness,
• closed and open-eye visual phenomena,
• synaesthesiaa condition in which normally separate senses are fused, in which one type of stimulation evokes the sensation of another, as when the hearing of a sound produces the visualisation of a colour More (especially in conjunction with music),
• peripheral stimulationcan be defined as any changes in a person's energy levels which are interpreted as stimulating and encouraging when it comes to movement and physical activities such as running, walking, cleaning, socializing, dancing, and climbing More,
• increased cardiovascular activity,
• increased perspiration ⁴.

• nausea,
• vomiting,
• unwanted spiritual experiences,
• tension,
• anxiety,
• intense feelings of dread and doom ⁴.

Tolerancethis is the process by which the receptors in your brain become habituated to the action of a drug. When tolerance is reached, more of the drug is required to achieve the same effect. With benzodiazepines, and probably with many other classes of drugs as well, tolerance is virtually always associated with some degree of physical dependence. If you find that you are experiencing tolerance, this is a clear warning sign that you may have formed a dependence. More to peyote or mescaline typically develops rapidly with repeated daily use, generally within 3 – 6 days. Cross-tolerance may also occur with other drugs including LSD and psilocybin. With a period of abstinence of at least a few days, ‘desired sensitivity is restored’ ⁸.

Mescaline is not physically addictive, but like other hallucinogenic drugs you can become tolerant to their effects. This means you need to take more of it to get the same effect as before ¹.

• αMT ⁶.

• Tramadol – this combination can cause seizuresthe outward effect can vary from uncontrolled jerking movement (tonic-clonic seizure) to as subtle as a momentary loss of awareness More due to the lowering of the threshold by tramadol and the potential of mescaline to cause seizuresthe outward effect can vary from uncontrolled jerking movement (tonic-clonic seizure) to as subtle as a momentary loss of awareness More ⁶.

Mescaline can be detected in the urine for 2 – 3 days ¹⁴.

There is some data available that indicates Mescaline can be detected in the blood for up to 24 hours ¹⁴.

A saliva test can detect Mescaline for up to 1 – 10 days ¹⁴.

Mescaline, like many other drugs, can be detected with a hair follicle drug test for up to 90 days ¹⁴.

• Like drinking and driving, driving whilst impaired due to use of drugs is illegal – and you could still be unfit to drive the day after using mescaline. You can get a heavy fine, be disqualified from driving or even go to prison ¹.