MDEA

• threshold – 50 – 70 mg,
• light – 70 – 120 mg ⁴, 80 – 100 mg ⁵,
• common – 120 – 180 mg ⁴, 100 – 150 mg ⁵,
• strong – 180 – 225 mg ⁴, 150 – 200 mg ⁵,
• heavy – 225 mg + ⁴.

• oral – 20 – 60 minutes ⁴.
• all ROA’sroute of administration - where the drug gets into your body – 30 – 60 minutes ⁵.
• oral – 140 mg – 20 – 85 minutes ⁶.
• oral – 160 mg – 40 minutes ⁷.

• oral – 15 – 30 minutes ⁴.

• oral – 90 – 120 minutes ⁴.

• oral – 1 – 2 hours ⁴.

• oral – 3 – 5 hours ⁴.
• all ROA’sroute of administration - where the drug gets into your body – 3 – 6 hours ⁵,
• oral – 140 mg – 2 – 3 hours ⁶,
• oral – 160 mg – 3 – 5 hours ⁷.

• oral – 12 – 48 hours ⁴.

MDEA is usually taken orally, rarely nasally or as a suppository. As amines, all RSAs are soluble in water and alcohol ¹¹, ¹², and can, therefore, be injected. Their inhalation as a vapour is impossible due to their high boiling points ¹³.

Exact toxiccapable of causing injury or death dosage is unknown ⁴. The oral LD50the amount of a material, given all at once, which causes the death of 50% (one half) of a group of test animals. The LD50 is one way to measure the short-term poisoning potential (acute toxicity) of a material value in the rat is 4.78 g/kg and the dermal LD50the amount of a material, given all at once, which causes the death of 50% (one half) of a group of test animals. The LD50 is one way to measure the short-term poisoning potential (acute toxicity) of a material value in the albino rabbit is 6.24 g/kg ¹.

On the basis of acute studies with laboratory animals, methyldiethanolamine is considered slightly toxiccapable of causing injury or death by single oral dose and practically nontoxic by single dermal application ¹.

Tolerancethis is the process by which the receptors in your brain become habituated to the action of a drug. When tolerance is reached, more of the drug is required to achieve the same effect. With benzodiazepines, and probably with many other classes of drugs as well, tolerance is virtually always associated with some degree of physical dependence. If you find that you are experiencing tolerance, this is a clear warning sign that you may have formed a dependence. More to many of the effects of MDEA develops with prolonged and repeated use. This results in users having to administer increasingly larger doses to achieve the same effects. After that, it takes about 1 – 1.5 months for the tolerancethis is the process by which the receptors in your brain become habituated to the action of a drug. When tolerance is reached, more of the drug is required to achieve the same effect. With benzodiazepines, and probably with many other classes of drugs as well, tolerance is virtually always associated with some degree of physical dependence. If you find that you are experiencing tolerance, this is a clear warning sign that you may have formed a dependence. More to be reduced to half and 2 – 3 months to be back at baseline (in the absence of further consumption). MDEA presents cross-tolerance with all dopaminergic and serotonergic stimulants and entactogens, meaning that after the consumption of MDEA all of these will have a reduced effect ⁴.

• physical euphoriaan intense feeling of pleasure and well-being More,
• pupil dilation,
• spontaneous physical sensations,
• bodily control enhancement,
• perception of bodily heaviness,
• stamina enhancement,
• stimulationcan be defined as any changes in a person's energy levels which are interpreted as stimulating and encouraging when it comes to movement and physical activities such as running, walking, cleaning, socializing, dancing, and climbing More,
• tactile enhancement,
• appetite suppression,
• sedationthe state of being relaxed or sleepy because of a drug More,
• brain zaps,
• dehydration,
• difficulty urinating,
• increased blood pressure,
• increased heart rate,
• increased perspiration,
• teeth grinding,
• temperature regulation suppression,
• temporary erectile dysfunction ⁴.

• anxiety,
• cognitive euphoriastate of intense well-being, happiness, and excitement More,
• compulsive redosing,
• depression,
• irritability,
• mindfulness,
• time distortion,
• creativity enhancement,
• dream potentiationcan be described as a cognitive component which increases the intensity, vividness and frequency of sleeping dream states. This effect also creates higher detail and definition within dreams alongside of an increase in the likelihood of one's dreams becoming lucid. More,
• empathy, affection and sociability enhancement,
• focus enhancement,
• immersion enhancementThis is an effect which can be described as a pronounced increase in one's ability to become fully engulfed within external visual or auditory stimuli such as music, movies, video games and various other forms of media. More,
• increased libido,
• increased music appreciation,
• motivation enhancement,
• stamina enhancement,
• thought acceleration,
• wakefulness,
• anxiety suppression,
• cognitive fatiguethe decline in the ability to think effectively and maintain focus. More,
• disinhibition,
• dream suppression,
• motivation suppression,
• thought deceleration,
• existential self-realisation,
• unity and interconnectedness ⁴.

• colour enhancement,
• pattern recognition enhancement,
• symmetrical texture repetition,
• tracers,
• double vision,
• vibrating vision,
• peripheral information misinterpretation ⁴.

• auditory distortion,
• auditory enhancement,
• auditory hallucinationswhere someone sees, hears, smells, tastes or feels things that don't exist outside of their mind ⁴.

Reported overdose symptoms of MDEA include the following –

• disseminated intravascular coagulationa condition in which blood clots form throughout the body's small blood vessels. These blood clots can reduce or block blood flow through the blood vessels, which can damage the body's organs. More,
• muscle rigidity,
• rhabdomyolysisa condition that may occur when muscle tissue is damaged due to an injury in which muscle in the body is damaged More,
• convulsionswhen your body shakes violently without you meaning it to,
• tachycardiarapid pulse rate,
• hypotensionlow blood pressure More,
• sweating ¹⁴.

As with other stimulants, the chronic use of MDEA can be considered moderately addictive with a high potential for abuse and is capable of causing psychological dependence among certain users. When addiction has developed, cravings and withdrawal effects may occur if a person suddenly stops their usage ⁴.

• αMT,
• Tramadol – Tramadol and stimulants both increase the risk of seizuresthe outward effect can vary from uncontrolled jerking movement (tonic-clonic seizure) to as subtle as a momentary loss of awareness More.
• MAOIsMAOIs may be used to treat the symptoms of depression. More – MAO-B inhibitors can increase the potency and duration of phenethylamines unpredictably. MAO-A inhibitors with amphetamine can lead to hypertensive crises ⁵.

• DOx – The combined stimulating effects of the two can lead to an uncomfortable body-load, while the focusing effects of amphetamine can easily lead to thought loops. Coming down from amphetamines while the DOx is still active can be quite anxiogenicsomething that causes anxiety More.
• NBOMes – Amphetamines and NBOMes both provide considerable stimulationcan be defined as any changes in a person's energy levels which are interpreted as stimulating and encouraging when it comes to movement and physical activities such as running, walking, cleaning, socializing, dancing, and climbing More. When combined they can result in tachycardiarapid pulse rate, hypertensionhigh blood pressure, vasoconstrictionnarrowing of the blood vessels resulting from contraction of the muscular wall of the vessels (in particular the large arteries and small arterioles) and in extreme cases heart failure. The anxiogenicsomething that causes anxiety More and focusing effects of stimulants are also not good in combination with psychedelics as they can lead to unpleasant thought loops. NBOMes are known to cause seizuresthe outward effect can vary from uncontrolled jerking movement (tonic-clonic seizure) to as subtle as a momentary loss of awareness More and stimulants can increase this risk.
• 2C-T-x – Stimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences. In extreme cases, they can result in severe vasoconstrictionnarrowing of the blood vessels resulting from contraction of the muscular wall of the vessels (in particular the large arteries and small arterioles), tachycardiarapid pulse rate, hypertensionhigh blood pressure, and in extreme cases heart failure.
• 5-MeO-xxT – The anxiogenicsomething that causes anxiety More and focusing effects of stimulants increase the chance of unpleasant thought loops. The combination is generally unnecessary because of the stimulating effects of psychedelics.
• DXM – Both substances raise heart rate, in extreme cases, panic attacks caused by these drugs have led to more serious heart issues.
• PCP – This combination can easily lead to hypermanic states ⁵.