Tramadol

• relaxation,
• sleepiness,
• pain relief,
• mild euphoriafeelings of joy and happiness,
• warmth,
• well-being ².

• dizziness,
• nausea,
• constipationmeans that you're not passing stools regularly or you're unable to completely empty your bowels. More,
• dry mouth,
• headaches,
• sleepiness,
• sweating,
• tiredness,
• vomiting ².

• oral – 15 – 60 minutes ³, 1 – 2 hours ⁴.

• oral – 2 – 6 hours ³, 3 – 4 hours ⁴.

• oral – 2 – 4 hours ³.

• oral – 6 – 10 hours ³, 5 – 7 hours ⁴.

• Oral – 68% – 72%,
• Rectal – 77% ³.

Tramadol has a low toxicityThis is when too much of something is taken over a short period of time More relative to dose. As with all opioids, long-term effects can vary but can include diminished libido, apathy and memory loss. It is also potentially lethal when mixed with depressants like alcohol or benzodiazepines and generally has a wider range of substances which it is dangerous to combine with in comparison to other opioids. It should not be taken during benzodiazepine withdrawal as this can potentially cause seizuresthe outward effect can vary from uncontrolled jerking movement (tonic-clonic seizure) to as subtle as a momentary loss of awareness More ³.

As with other opioids, the chronic use of tramadol can be considered moderately addictive with a high potential for abuse and is capable of causing psychological dependence among certain users. When addiction has developed, cravings and withdrawal symptoms may occur if a person suddenly stops their usage.

Tolerancethis is the process by which the receptors in your brain become habituated to the action of a drug. When tolerance is reached, more of the drug is required to achieve the same effect. With benzodiazepines, and probably with many other classes of drugs as well, tolerance is virtually always associated with some degree of physical dependence. If you find that you are experiencing tolerance, this is a clear warning sign that you may have formed a dependence. More to many of the effects of tramadol develops with prolonged and repeated use. The rate at which this occurs develops at different rates for different effects, with tolerancethis is the process by which the receptors in your brain become habituated to the action of a drug. When tolerance is reached, more of the drug is required to achieve the same effect. With benzodiazepines, and probably with many other classes of drugs as well, tolerance is virtually always associated with some degree of physical dependence. If you find that you are experiencing tolerance, this is a clear warning sign that you may have formed a dependence. More to the constipation-inducing effects developing particularly slowly for instance. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about 3 – 7 days for the tolerancethis is the process by which the receptors in your brain become habituated to the action of a drug. When tolerance is reached, more of the drug is required to achieve the same effect. With benzodiazepines, and probably with many other classes of drugs as well, tolerance is virtually always associated with some degree of physical dependence. If you find that you are experiencing tolerance, this is a clear warning sign that you may have formed a dependence. More to be reduced to half and 1 – 2 weeks to be back at baseline (in the absence of further consumption). Tramadol presents cross-tolerance with all other opioids, meaning that after the consumption of tramadol all opioids will have a reduced effect ³.

• fatiguea feeling of weariness, tiredness, or lack of energy. More,
• drowsiness,
• nausea,
• retching,
• constipationmeans that you're not passing stools regularly or you're unable to completely empty your bowels. More,
• confusiontrouble focusing, slow or disorganised thinking, poor short-term memory, unsure of time or place, or having difficulty following a conversation ¹.

• diarrhoeaWhere you frequently pass watery or loose faeces,
• dizziness,
• fainting,
• excessive sweating,
• itching,
• raised blood pressure,
• tightness in the airways,
• muscle weakness,
• sensory disturbances,
• hallucinationswhere someone sees, hears, smells, tastes or feels things that don't exist outside of their mind,
• fits,
• blood disorders ¹.

• physical euphoriaan intense feeling of pleasure and well-being More,
• pupil constriction,
• stimulationcan be defined as any changes in a person's energy levels which are interpreted as stimulating and encouraging when it comes to movement and physical activities such as running, walking, cleaning, socializing, dancing, and climbing More,
• appetite suppression,
• cough suppression,
• orgasm suppression,
• pain relief,
• sedationthe state of being relaxed or sleepy because of a drug More,
• constipationmeans that you're not passing stools regularly or you're unable to completely empty your bowels. More,
• difficulty urinating,
• itchiness,
• nausea ³.

• cognitive euphoriastate of intense well-being, happiness, and excitement More,
• compulsive redosing,
• dream potentiationcan be described as a cognitive component which increases the intensity, vividness and frequency of sleeping dream states. This effect also creates higher detail and definition within dreams alongside of an increase in the likelihood of one's dreams becoming lucid. More,
• thought acceleration,
• anxiety suppression,
• decreased libido ³.

• euphoriafeelings of joy and happiness,
• pain relief,
• elevated mood,
• overall feeling of contentedness ⁴.

• itching ⁴.

Some users may experience –

• nausea,
• constipationmeans that you're not passing stools regularly or you're unable to completely empty your bowels. More,
• CNSthe Central Nervous System, upon which certain drugs act depression,
• drowsiness,
• hot/cold flashes,
• dizziness,
• vomiting,
• urinary retentiondifficulty urinating. More ⁴.

In high doses, overdoses, or in patients not tolerant to opiates, tramadol can cause –

• shallow breathing,
• bradycardiawhen the heart beats very slowly,
• cold-clammy skin,
• apnoeaSuspension of breathing. During apnoea, there is no movement of the muscles of inhalation, and the volume of the lungs initially remains unchanged. More,
• hypotensionlow blood pressure More,
• miosisa medical condition characterised by contraction of the pupil for reasons other than increased light levels. More,
• circulatory collapse,
• respiratory arrestRespiratory arrest is caused by airway obstruction, decreased respiratory drive, or respiratory muscle weakness. More,
• death ⁴.

• nausea,
• vomiting,
• constipationmeans that you're not passing stools regularly or you're unable to completely empty your bowels. More,
• lightheadedness or dizziness,
• drowsiness,
• headache,
• loss of appetite,
• dry mouth ¹⁷.

• sleepiness,
• unconsciousness,
• coma,
• seizuresthe outward effect can vary from uncontrolled jerking movement (tonic-clonic seizure) to as subtle as a momentary loss of awareness More,
• respiratory depressionslowing the drive and effectiveness of breathing More,
• abnormally low blood pressure,
• slow heart rate,
• sweating or clammy skin,
• weak muscles,
• pinpointthe pupils are very small. More pupils ¹⁶,
• irregular heart rhythm,
• vomiting,
• hyperthermiaThis is a condition in which the body's temperature is higher than normal More,
• muscle rigidity,
• muscle pain,
• limp or weakened body,
• cyanosisbluish tinge to fingers and lips, caused by inadequate blood supply ¹⁸.

• insomniadifficulty in going to sleep or in getting enough sleep,
• muscle tension,
• headache,
• shakiness,
• feeling nervous or worried,
• shifting moods/irritability,
• sexual dysfunction,
• problems with breathing,
• difficulty swallowing,
• hoarseness,
• hallucinationswhere someone sees, hears, smells, tastes or feels things that don't exist outside of their mind,
• dry mouth,
• heartburn,
• poor appetite,
• nausea and vomiting,
• constipationmeans that you're not passing stools regularly or you're unable to completely empty your bowels. More,
• drowsiness,
• loss of consciousness,
• an inability to smell,
• nosebleeds,
• runny nose,
• difficulty swallowing ¹⁸.

• tolerancethis is the process by which the receptors in your brain become habituated to the action of a drug. When tolerance is reached, more of the drug is required to achieve the same effect. With benzodiazepines, and probably with many other classes of drugs as well, tolerance is virtually always associated with some degree of physical dependence. If you find that you are experiencing tolerance, this is a clear warning sign that you may have formed a dependence. More,
• physical dependence,
• psychological dependence,
• withdrawal symptoms,
• increased risk of adverse effects ².

Tramadol is addictive.

Over time, using tramadol produces ‘cravings’ and a psychological desire to keep on using.

Tolerancethis is the process by which the receptors in your brain become habituated to the action of a drug. When tolerance is reached, more of the drug is required to achieve the same effect. With benzodiazepines, and probably with many other classes of drugs as well, tolerance is virtually always associated with some degree of physical dependence. If you find that you are experiencing tolerance, this is a clear warning sign that you may have formed a dependence. More can also build, so that users have to take more just to get the same effects or to avoid an unpleasant withdrawal ³.

• αMT,
• Ketamine,
• MXE,
• DXM,
• PCP,
• Amphetamines – Tramadol and stimulants both increase the risk of seizuresthe outward effect can vary from uncontrolled jerking movement (tonic-clonic seizure) to as subtle as a momentary loss of awareness More.
• MDMA – Tramadol and stimulants both increase the risk of seizuresthe outward effect can vary from uncontrolled jerking movement (tonic-clonic seizure) to as subtle as a momentary loss of awareness More.
• Cocaine – Tramadol and stimulants both increase the risk of seizuresthe outward effect can vary from uncontrolled jerking movement (tonic-clonic seizure) to as subtle as a momentary loss of awareness More.
• Alcohol – Heavy CNSthe Central Nervous System, upon which certain drugs act depressants, risk of seizuresthe outward effect can vary from uncontrolled jerking movement (tonic-clonic seizure) to as subtle as a momentary loss of awareness More. Both substances potentiate the ataxialoss of motor coordination More and sedationthe state of being relaxed or sleepy because of a drug More caused by the other and can lead to unexpected loss of consciousness at high doses. Place affected patients in the recovery position to prevent vomit aspirationvomit being inhaled into the lungs, a potentially life-threatening condition More from excess. Memory blackouts are likely.
• GHB/GBL – The sedativeOne of a diverse group of drugs manufactured for medical purposes to relax the central nervous system. More effects of this combination can lead to dangerous respiratory depressionslowing the drive and effectiveness of breathing More.
• Opioids – Concomitant use of tramadol increases the seizure risk in patients taking other opioids. These agents are often individually epileptogenic and may have additive effects on seizure threshold during coadministration. Central nervous system- and/or respiratory-depressant effects may be additively or synergisticallyThe effect arising between two or more agents, entities, factors, or substances that produce an effect greater than the sum of their individual effects. More present.
• Benzodiazepines – Central nervous system- and/or respiratory-depressant effects may be additively or synergisticallyThe effect arising between two or more agents, entities, factors, or substances that produce an effect greater than the sum of their individual effects. More present. Vomit aspirationvomit being inhaled into the lungs, a potentially life-threatening condition More a risk when passed out, lay down in recovery position if ingested.
• MAOIsMAOIs may be used to treat the symptoms of depression. More,
• SSRIs ³.

• Mushrooms – Tramadol is well known to lower seizure threshold and psychedelics also cause occasional seizuresthe outward effect can vary from uncontrolled jerking movement (tonic-clonic seizure) to as subtle as a momentary loss of awareness More.
• LSD – Tramadol is well known to lower seizure threshold and psychedelics also cause occasional seizuresthe outward effect can vary from uncontrolled jerking movement (tonic-clonic seizure) to as subtle as a momentary loss of awareness More.
• DMT – Tramadol is well known to lower seizure threshold and psychedelics also cause occasional seizuresthe outward effect can vary from uncontrolled jerking movement (tonic-clonic seizure) to as subtle as a momentary loss of awareness More.
• Mescaline – This combination can cause seizuresthe outward effect can vary from uncontrolled jerking movement (tonic-clonic seizure) to as subtle as a momentary loss of awareness More due to the lowering of the threshold by tramadol and the potential of mescaline to cause seizuresthe outward effect can vary from uncontrolled jerking movement (tonic-clonic seizure) to as subtle as a momentary loss of awareness More.
• DOx – Tramadol is well known to lower seizure threshold and psychedelics also cause occasional seizuresthe outward effect can vary from uncontrolled jerking movement (tonic-clonic seizure) to as subtle as a momentary loss of awareness More.
• NBOMes – Tramadol is well known to lower seizure threshold and NBOMes have also shown a tendency to cause severe seizuresthe outward effect can vary from uncontrolled jerking movement (tonic-clonic seizure) to as subtle as a momentary loss of awareness More.
• 2C-x – Tramadol is well known to lower seizure threshold and psychedelics raise the risk of seizuresthe outward effect can vary from uncontrolled jerking movement (tonic-clonic seizure) to as subtle as a momentary loss of awareness More.
• 2C-T-x,
• 5-MeO-xxT ³.

• Nitrous oxide – Both substances potentiate the ataxialoss of motor coordination More and sedationthe state of being relaxed or sleepy because of a drug More caused by the other and can lead to unexpected loss of consciousness at high doses. While unconscious, vomit aspirationvomit being inhaled into the lungs, a potentially life-threatening condition More is a risk if not placed in the recovery position. Memory blackouts are likely ³.

Combinations in the list below may increase the amount of neurotransmitters such as serotonin and dopamine to dangerous or even fatal levels ³.

• MAOIsMAOIs may be used to treat the symptoms of depression. More such as syrian rue, banisteriopsis caapi, 2C-T-2, 2C-T-7, αMT, and some antidepressants,
• Serotonin releasers such as MDMA, 4-FA, MDAI and αMT,
• Selective serotonin re-uptake inhibitors (SSRIs),
• Serotonin-norepinephrine reuptake inhibitors (SNRIs),
• 5-HTP ³.

See Serotonin syndrome for more information.

• days 1 – 3 – onset of general withdrawal symptoms, including feelings of pins and needles, sweating, nervousness, nausea, anxiety, palpitations, insomniadifficulty in going to sleep or in getting enough sleep and drug cravings.
• days 4 – 7 – drug cravings persist, along with insomniadifficulty in going to sleep or in getting enough sleep, disorientation and confusiontrouble focusing, slow or disorganised thinking, poor short-term memory, unsure of time or place, or having difficulty following a conversation, and blurred vision.
• days 8 – 14 – symptoms should be fairly mild by this point. Depression, anxiety, and irrational thoughts may persist ¹⁶.

• If the Police arrest you in possession of tramadol unlawfully, they’ll always take some action. This could be a formal caution or arrest and possible conviction.
• Having tramadol that is not prescribed for you for your own use (called illegal possession) could result in up to two years in prison and/or an unlimited fine. While selling or giving tramadol away for free, even to friends (called supplying) could result in up to fourteen years in prison and/or an unlimited fine.
• A conviction for a drug-related offence could have a serious impact. It could make it harder, even impossible, to visit certain countries- for example the United States – and limit the types of jobs you can apply for ¹.

• Allowing other people to supply drugs in your house or any other premises is illegal. If the police catch people supplying illegal drugs in a club they can potentially prosecute the landlord, club owner or any person concerned in the management of the premises.
• Like drinking and driving, driving when high is illegal – and you can still be unfit to drive the day after using tramadol. You can get a heavy fine, be disqualified from driving or even go to prison ¹.