Methylone

• euphoriafeelings of joy and happiness,
• stimulationcan be defined as any changes in a person's energy levels which are interpreted as stimulating and encouraging when it comes to movement and physical activities such as running, walking, cleaning, socializing, dancing, and climbing More,
• feeling of ‘one-ness’,
• empathy ¹.

• muscle tension,
• nausea and vomiting,
• increased heart rate,
• dizziness and confusiontrouble focusing, slow or disorganised thinking, poor short-term memory, unsure of time or place, or having difficulty following a conversation,
• teeth-grinding (‘gurning’) ¹.

• threshold – 60 – 100 mg,
• light – 100 – 150 mg,
• common – 150 – 225 mg,
• strong – 225 – 325 mg,
• heavy – 325 mg + ².

• oral – 15 – 60 minutes ².

• oral – 60 – 90 minutes ².

• oral – 60 – 120 minutes ².

• oral – 2 – 4 hours ².

• oral – 6 – 24 hour ².

The toxicityThis is when too much of something is taken over a short period of time More and long-term health effects of recreational methylone use do not seem to have been studied in any scientific context and the exact toxiccapable of causing injury or death dosage is unknown ².

Tolerancethis is the process by which the receptors in your brain become habituated to the action of a drug. When tolerance is reached, more of the drug is required to achieve the same effect. With benzodiazepines, and probably with many other classes of drugs as well, tolerance is virtually always associated with some degree of physical dependence. If you find that you are experiencing tolerance, this is a clear warning sign that you may have formed a dependence. More to many of the effects of methylone develops with prolonged and repeated use. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about 3 – 7 days for the tolerancethis is the process by which the receptors in your brain become habituated to the action of a drug. When tolerance is reached, more of the drug is required to achieve the same effect. With benzodiazepines, and probably with many other classes of drugs as well, tolerance is virtually always associated with some degree of physical dependence. If you find that you are experiencing tolerance, this is a clear warning sign that you may have formed a dependence. More to be reduced to half and 1 – 2 weeks to be back at baseline (in the absence of further consumption). Methylone presents cross-tolerance with all dopaminergic stimulants, meaning that after the consumption of methylone all stimulants will have a reduced effect ².

Abuse of compounds within the stimulanta drug that acts on the Central Nervous System, increasing some rates of function such as heart-rate class at high dosages for prolonged periods of time can potentially result in a stimulanta drug that acts on the Central Nervous System, increasing some rates of function such as heart-rate psychosis that may present with a variety of symptoms (e.g., paranoiasuspicion, distrust or fear of other people, hallucinationswhere someone sees, hears, smells, tastes or feels things that don't exist outside of their mind, or delusions) ³. A review on treatment for amphetamine, dextroamphetamine, and methamphetamine abuse-induced psychosis states that about 5% – 15% of users fail to recover completely ³, ⁴. The same review asserts that, based upon at least one trial, antipsychotic medications effectively resolve the symptoms of acute amphetamine psychosis ³. Psychosis very rarely arises from therapeutic use ².

• spontaneous physical sensations,
• stimulationcan be defined as any changes in a person's energy levels which are interpreted as stimulating and encouraging when it comes to movement and physical activities such as running, walking, cleaning, socializing, dancing, and climbing More,
• tactile enhancement,
• dehydration,
• difficulty urinating,
• increased blood pressure,
• increased heart rate,
• increased perspiration,
• teeth grinding,
• temperature regulation suppression ².

• anxiety,
• cognitive euphoriastate of intense well-being, happiness, and excitement More,
• depression,
• irritability,
• mindfulness,
• time distortion,
• analysis enhancementbest described as a subtle to distinct enhancement of one's overall ability to process information and logically or creatively analyse concepts, ideas and scenarios. The experience of this leads onto deep and complex states of contemplation which often result in an abundance of new and insightful ideas. This gives the person a powerful ability to dissect and rationally analyse concepts and problems, allowing them to gain insights and reach new conclusions, perspectives and solutions which would have been otherwise difficult to conceive of. More,
• increased libido,
• increased music appreciation,
• thought acceleration,
• wakefulness,
• cognitive fatiguethe decline in the ability to think effectively and maintain focus. More,
• motivation suppression,
• thought deceleration ².

• vibrating vision ².

The effects which occur during the offset of a stimulanta drug that acts on the Central Nervous System, increasing some rates of function such as heart-rate experience generally feel negative and uncomfortable in comparison to the effects which occurred during its peak. This is often referred to as a “comedown” and occurs because of neurotransmitter depletion ². Its effects commonly include –

• anxiety,
• cognitive fatiguethe decline in the ability to think effectively and maintain focus. More,
• depression,
• irritability,
• motivation suppression,
• thought deceleration,
• wakefulness ².

As with other stimulants, the chronic use of methylone can be considered moderately addictive with a high potential for abuse and is capable of causing psychological dependence among certain users. When addiction has developed, cravings and withdrawal effects may occur if a person suddenly stops their usage ².

• αMT,
• Tramadol – Tramadol and stimulants both increase the risk of seizuresthe outward effect can vary from uncontrolled jerking movement (tonic-clonic seizure) to as subtle as a momentary loss of awareness More,
• MAOIsMAOIs may be used to treat the symptoms of depression. More – MAO-B inhibitors can increase the potency and duration of phenethylamines unpredictably. MAO-A inhibitors with amphetamine can lead to hypertensive crises ⁵.

• DOx – The combined stimulating effects of the two can lead to an uncomfortable body-load, while the focusing effects of amphetamine can easily lead to thought loops. Coming down from amphetamines while the DOx is still active can be quite anxiogenicsomething that causes anxiety More.
• NBOMes – Amphetamines and NBOMes both provide considerable stimulationcan be defined as any changes in a person's energy levels which are interpreted as stimulating and encouraging when it comes to movement and physical activities such as running, walking, cleaning, socializing, dancing, and climbing More. When combined they can result in tachycardiarapid pulse rate, hypertensionhigh blood pressure, vasoconstrictionnarrowing of the blood vessels resulting from contraction of the muscular wall of the vessels (in particular the large arteries and small arterioles) and in extreme cases heart failure. The anxiogenicsomething that causes anxiety More and focusing effects of stimulants are also not good in combination with psychedelics as they can lead to unpleasant thought loops. NBOMes are known to cause seizuresthe outward effect can vary from uncontrolled jerking movement (tonic-clonic seizure) to as subtle as a momentary loss of awareness More and stimulants can increase this risk.
• 2C-T-x – Stimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences. In extreme cases, they can result in severe vasoconstrictionnarrowing of the blood vessels resulting from contraction of the muscular wall of the vessels (in particular the large arteries and small arterioles), tachycardiarapid pulse rate, hypertensionhigh blood pressure, and in extreme cases heart failure.
• 5-MeO-xxT – The anxiogenicsomething that causes anxiety More and focusing effects of stimulants increase the chance of unpleasant thought loops. The combination is generally unnecessary because of the stimulating effects of psychedelics.
• DXM – Both substances raise heart rate, in extreme cases, panic attacks caused by these drugs have led to more serious heart issues.
• PCP – This combination can easily lead to hypermanic states ⁵.