Also known as
4-bromo-2, 5-dimethoxyamphetamine
Classification
Psychedelic
Dosage
Abuse
- threshold – 500 ug,
- light – 750 ug,
- common – 750 – 100 ug,
- heavy – 1100 – 1500 ug,
- dangerous – 3000 ug 1.
How long do its effects last?
Onset of effects
Peak
- oral – 3 – 8 hours 2.
Offset
- oral – 3 – 8 hours 2.
Duration of effects
Pharmacology
DOB’s psychedelic effects are believed to come from its efficacy at the 5-HT2A receptor as a partial agonist. Due to its selectivity, DOB is often used in scientific research when studying the 5-HT2 receptor subfamily. It has been suggested that DOB is a prodrug metabolised in the lungs 3, 4.
However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive 2.
Tolerance
DOB is not habit-forming and the desire to use it can actually decrease with use. It is most often self-regulating.
Tolerancethis is the process by which the receptors in your brain become habituated to the action of a drug. When tolerance is reached, more of the drug is required to achieve the same effect. With benzodiazepines, and probably with many other classes of drugs as well, tolerance is virtually always associated with some degree of physical dependence. If you find that you are experiencing tolerance, this is a clear warning sign that you may have formed a dependence. More to the effects of DOB are built almost immediately after ingestion. After that, it takes about 3 days for the tolerancethis is the process by which the receptors in your brain become habituated to the action of a drug. When tolerance is reached, more of the drug is required to achieve the same effect. With benzodiazepines, and probably with many other classes of drugs as well, tolerance is virtually always associated with some degree of physical dependence. If you find that you are experiencing tolerance, this is a clear warning sign that you may have formed a dependence. More to be reduced to half and 7 days to be back at baseline (in the absence of further consumption). DOB presents cross-tolerance with all psychedelics, meaning that after the consumption of DOB all psychedelics will have a reduced effect 2.
Effects
Physical effects
- pupil dilation,
- spontaneous physical sensations,
- stimulationcan be defined as any changes in a person's energy levels which are interpreted as stimulating and encouraging when it comes to movement and physical activities such as running, walking, cleaning, socializing, dancing, and climbing More,
- tactile enhancement,
- diarrhoeaWhere you frequently pass watery or loose faeces,
- increased blood pressure,
- increased heart rate,
- nausea,
- vasoconstrictionnarrowing of the blood vessels resulting from contraction of the muscular wall of the vessels (in particular the large arteries and small arterioles) 2.
Cognitive effects
- conceptual thinking,
- time distortion,
- analysis enhancementbest described as a subtle to distinct enhancement of one's overall ability to process information and logically or creatively analyse concepts, ideas and scenarios. The experience of this leads onto deep and complex states of contemplation which often result in an abundance of new and insightful ideas. This gives the person a powerful ability to dissect and rationally analyse concepts and problems, allowing them to gain insights and reach new conclusions, perspectives and solutions which would have been otherwise difficult to conceive of. More,
- emotionality enhancement,
- immersion enhancementThis is an effect which can be described as a pronounced increase in one's ability to become fully engulfed within external visual or auditory stimuli such as music, movies, video games and various other forms of media. More,
- increased music appreciation,
- novelty enhancement,
- thought acceleration,
- wakefulness,
- memory suppression 2.
Visual effects
- acuity enhancement,
- colour enhancement,
- pattern recognition enhancement,
- after images,
- colour shifting,
- drifting,
- scenery slicingbest described as an effect which only occurs spontaneously and rarely sustains itself for more than several seconds. The experience of this effect splits the visual field into separate sections. These individual slices then proceed to drift slowly away from their original position before disappearing and resetting to normality. More,
- symmetrical texture repetition,
- tracers,
- geometrybest described as the experience of a person's field of vision being partially or completely encompassed by fast-moving, colourful and indescribably complex geometric patterns, form constants, phosphenes, shapes, fractals, structures and colour. These geometric forms can also become structured and organised in a way that presents genuine information to the person experiencing it far beyond the perception of meaningless, although complex, shapes and colours. This happens through the experience of innately understood geometric representations that feel as though they depict specific concepts and neurological components that exist within the brain in a manner that is extremely detailed. More eventually leads to level 8a geometrybest described as the experience of a person's field of vision being partially or completely encompassed by fast-moving, colourful and indescribably complex geometric patterns, form constants, phosphenes, shapes, fractals, structures and colour. These geometric forms can also become structured and organised in a way that presents genuine information to the person experiencing it far beyond the perception of meaningless, although complex, shapes and colours. This happens through the experience of innately understood geometric representations that feel as though they depict specific concepts and neurological components that exist within the brain in a manner that is extremely detailed. More,
- autonomous entities,
- external hallucinationsbest described as the experience of perceiving imagined visual concepts and occurrences which display themselves seamlessly into the external environment as if they were actually happening. More,
- internal hallucinationsbest described as the perception of imagery and scenes which are experienced exclusively within a layer in front of one's open or closed eye vision and not seamlessly within the external environment around oneself. At lower levels, internal hallucinations begin with imagery which does not take up the entirety of one's visual field and is distinctively separate from its background. These can be described as spontaneous moving or still images of scenes, concepts, places, and anything one could imagine. They are manifested in varying levels of detail, ranging from ill-defined and cartoon-like in nature to completely realistic and beyond realism through seemingly impossible, non-euclidean geometric forms. They rarely hold their form for more than a few seconds before fading or shifting into another image. More,
- perspective alterations,
- scenarios and plots,
- settings, sceneries, and landscapes,
- transformations 2.
Auditory effects
- auditory distortion,
- auditory enhancement,
- auditory hallucinationswhere someone sees, hears, smells, tastes or feels things that don't exist outside of their mind 2.
Dangerous interactions
Unsafe
- DXM – The DOx class as psychedelic stimulants have the potential to mask the effects of DXM and could lead to redosing to an unsafe level. DXM can also potentiate DOx resulting in an unpleasantly intense experience.
- PCP – Details of this combination are not well understood but PCP generally interacts in an unpredictable manner.
- Amphetamines – The combined stimulating effects of the two can lead to an uncomfortable body-load, while the focusing effects of amphetamine can easily lead to thought loops. Coming down from amphetamines while the DOx is still active can be quite anxiogenicsomething that causes anxiety More.
- Cocaine – The combined stimulating effects of the two can lead to an uncomfortable body-load, while the focusing effects of cocaine can easily lead to thought loops. Coming down from cocaine while the DOx is still active can be quite anxiogenicsomething that causes anxiety More.
- Tramadol – Tramadol is well known to lower seizure threshold and psychedelics also cause occasional seizuresthe outward effect can vary from uncontrolled jerking movement (tonic-clonic seizure) to as subtle as a momentary loss of awareness More 1.
History
This substance has no history of human usage prior to the 1991 publication of its synthesis and documentation in his book PiHKAL (“Phenethylamines I Have Known And Loved”) by Alexander Shulgin 5.
Footnotes:
DOB, 2017, http://drugs.tripsit.me/dob
DOB, 2017, https://psychonautwiki.org/wiki/DOB
Shulgin, A. and Shulgin, A., #62 DOB, 2015, http://www.erowid.org/library/books_online/pihkal/pihkal062.shtml
Shulgin, A., DOB and Other Possible Prodrugs, 2005, http://www.cognitiveliberty.org/shulgin/blg/2005/05/dob-and-other-possible-prodrugs.html
Shulgin, A. and Shulgin, A., Phenethylamines I Have Known And Loved: A Chemical Love Story, 2015, https://www.erowid.org/library/books_online/pihkal/pihkal.shtml