DOB

Also known as

4-bromo-2, 5-dimethoxyamphetamine

Classification

Psychedelic

Dosage

Abuse

• threshold - 500 ug,
• light - 750 ug,
• common - 750 - 100 ug,
• heavy - 1100 - 1500 ug,
• dangerous - 3000 ug .

How long do its effects last?

Onset of effects

• oral - 30 - 90 minutes .
• all ROA's - 30 - 120 minutes .

Peak

• oral - 3 - 8 hours .

Offset

• oral - 3 - 8 hours .

Duration of effects

• oral - 7 - 24 hours .
• all ROA's - 8 - 24 hours .

After-effects

• oral - 4 - 8 hours .
• all ROA's - 2 - 12 hours .

Pharmacology

DOB's psychedelic effects are believed to come from its efficacy at the 5-HT2A receptor as a partial agonist. Due to its selectivity, DOB is often used in scientific research when studying the 5-HT2 receptor subfamily. It has been suggested that DOB is a prodrug metabolised in the lungs , .

However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive .

Tolerance

DOB is not habit-forming and the desire to use it can actually decrease with use. It is most often self-regulating.

Tolerance to the effects of DOB are built almost immediately after ingestion. After that, it takes about 3 days for the tolerance to be reduced to half and 7 days to be back at baseline (in the absence of further consumption). DOB presents cross-tolerance with all psychedelics, meaning that after the consumption of DOB all psychedelics will have a reduced effect .

Effects

Physical effects

• pupil dilation,
• spontaneous physical sensations,
• stimulation,
• tactile enhancement,
• diarrhoea,
• increased blood pressure,
• increased heart rate,
• nausea,
• vasoconstriction .

Cognitive effects

• conceptual thinking,
• time distortion,
• analysis enhancement,
• emotionality enhancement,
• immersion enhancement,
• increased music appreciation,
• novelty enhancement,
• thought acceleration,
• wakefulness,
• memory suppression .

Visual effects

• acuity enhancement,
• colour enhancement,
• pattern recognition enhancement,
• after images,
• colour shifting,
• drifting,
• scenery slicing,
• symmetrical texture repetition,
• tracers,
• geometry eventually leads to level 8a geometry,
• autonomous entities,
• external hallucinations,
• internal hallucinations,
• perspective alterations,
• scenarios and plots,
• settings, sceneries, and landscapes,
• transformations .

Auditory effects

• auditory distortion,
• auditory enhancement,
• auditory hallucinations .

Dangerous interactions

Dangerous

• αMT .

Unsafe

• DXM - The DOx class as psychedelic stimulants have the potential to mask the effects of DXM and could lead to redosing to an unsafe level. DXM can also potentiate DOx resulting in an unpleasantly intense experience.
• PCP - Details of this combination are not well understood but PCP generally interacts in an unpredictable manner.
• Amphetamines - The combined stimulating effects of the two can lead to an uncomfortable body-load, while the focusing effects of amphetamine can easily lead to thought loops. Coming down from amphetamines while the DOx is still active can be quite anxiogenic.
• Cocaine - The combined stimulating effects of the two can lead to an uncomfortable body-load, while the focusing effects of cocaine can easily lead to thought loops. Coming down from cocaine while the DOx is still active can be quite anxiogenic
• Tramadol - Tramadol is well known to lower seizure threshold and psychedelics also cause occasional seizures .

History

This substance has no history of human usage prior to the 1991 publication of its synthesis and documentation in his book PiHKAL ("Phenethylamines I Have Known And Loved") by Alexander Shulgin .

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