Citalopram - Revision history

Sharon: /* Incidence not known */

2017-04-25T10:03:52Z

‎Incidence not known

Sharon: /* Rare */

2017-04-25T10:02:26Z

‎Rare

Sharon: /* Pharmacodynamics */

2017-04-25T10:01:27Z

‎Pharmacodynamics

Sharon at 10:00, 25 April 2017

2017-04-25T10:00:28Z

Sharon at 14:44, 23 April 2017

2017-04-23T14:44:48Z

Sharon: /* References */

2017-04-23T14:40:15Z

‎References

Sharon at 14:38, 23 April 2017

2017-04-23T14:38:39Z

Sharon at 14:36, 23 April 2017

2017-04-23T14:36:38Z

Sharon at 14:25, 23 April 2017

2017-04-23T14:25:07Z

Sharon at 14:24, 23 April 2017

2017-04-23T14:24:09Z

@@ Line 253: / Line 253: @@
 * loss of bladder control,
 * loss of consciousness,
-* medical confusion * which is confusion as to time, place, or person,
+* medical confusion (which is confusion as to time, place, or person),
 * muscle cramps or spasms,
 * muscle tightness,

@@ Line 205: / Line 205: @@
 * increased thirst,
 * irregular heartbeat,
-* lack of energy]<
+* lack of energy,
 * lethargy,
 * nosebleed,

@@ Line 54: / Line 54: @@
 === Pharmacodynamics ===
-Citalopram is one of a class of antidepressants known as [[SSRI]]s. It is used to treat the depression associated with mood disorders. It is also used on occassion in the treatment of body dysmorphic disorder and anxiety. The antidepressant, antiobsessive-compulsive, and antibulimic actions of citalopram are presumed to be linked to its inhibition of [[CNS]] neuronal uptake of serotonin. [[Iin-vitro]] studies show that citalopram is a potent and selective inhibitor of neuronal serotonin reuptake and has only very weak effects on norepinephrine and dopamine neuronal reuptake. Citalopram has no significant affinity for adrenergic (α1, α2, β), cholinergic, GABA, dopaminergic, histaminergic, serotonergic (5HT1A, 5HT1B, 5HT2), or benzodiazepine receptors; antagonism of such receptors has been hypothesised to be associated with various anticholinergic, [[sedative]], and cardiovascular effects for other psychotropic drugs. The chronic administration of citalopram was found to downregulate brain norepinephrine receptors, as has been observed with other drugs effective in the treatment of major depressive disorder. Citalopram does not inhibit monoamine oxidase <ref name="2a"/>.
+Citalopram is one of a class of antidepressants known as [[SSRI]]s. It is used to treat the depression associated with mood disorders. It is also used on occassion in the treatment of body dysmorphic disorder and anxiety. The antidepressant, antiobsessive-compulsive, and antibulimic actions of citalopram are presumed to be linked to its inhibition of [[CNS]] neuronal uptake of serotonin. [[in-vitro]] studies show that citalopram is a potent and selective inhibitor of neuronal serotonin reuptake and has only very weak effects on norepinephrine and dopamine neuronal reuptake. Citalopram has no significant affinity for adrenergic (α1, α2, β), cholinergic, GABA, dopaminergic, histaminergic, serotonergic (5HT1A, 5HT1B, 5HT2), or benzodiazepine receptors; antagonism of such receptors has been hypothesised to be associated with various anticholinergic, [[sedative]], and cardiovascular effects for other psychotropic drugs. The chronic administration of citalopram was found to downregulate brain norepinephrine receptors, as has been observed with other drugs effective in the treatment of major depressive disorder. Citalopram does not inhibit monoamine oxidase <ref name="2a"/>.
 === Pharmacokinetics ===

@@ Line 10: / Line 10: @@
 Citalopram is an antidepressive agent that is [[FDA]] approved for the treatment of depression. There is a [[Black Box Warning]] for this drug as shown [[#Black Box Warning|here]]. Common adverse reactions include [[diaphoresis]], [[constipation]], [[diarrhoea]], nausea, vomiting, [[xerostomia]], dizziness, headache, insomnia, sedation, [[somnolence]], tremor, agitation, disorder of ejaculation, [[fatigue]] <ref name="3a">'''Citalopram''', 2015, http://www.wikidoc.org/index.php/Citalopram</ref>.
 == Why take it? ==
@@ Line 28: / Line 32: @@
 * withdrawal,
 * dietary restrictions (for maois) <ref name="4a"/>.
 == Abuse ==
@@ Line 38: / Line 54: @@
 === Pharmacodynamics ===
-Citalopram is one of a class of antidepressants known as [[SSRI]]s. It is used to treat the depression associated with mood disorders. It is also used on occassion in the treatment of body dysmorphic disorder and anxiety. The antidepressant, antiobsessive-compulsive, and antibulimic actions of citalopram are presumed to be linked to its inhibition of [[CNS]] neuronal uptake of serotonin. [[in-vitro]] studies show that citalopram is a potent and selective inhibitor of neuronal serotonin reuptake and has only very weak effects on norepinephrine and dopamine neuronal reuptake. Citalopram has no significant affinity for adrenergic (α1, α2, β), cholinergic, GABA, dopaminergic, histaminergic, serotonergic (5HT1A, 5HT1B, 5HT2), or benzodiazepine receptors; antagonism of such receptors has been hypothesised to be associated with various anticholinergic, [[sedative]], and cardiovascular effects for other psychotropic drugs. The chronic administration of citalopram was found to downregulate brain norepinephrine receptors, as has been observed with other drugs effective in the treatment of major depressive disorder. Citalopram does not inhibit monoamine oxidase <ref name="2a"/>.
+Citalopram is one of a class of antidepressants known as [[SSRI]]s. It is used to treat the depression associated with mood disorders. It is also used on occassion in the treatment of body dysmorphic disorder and anxiety. The antidepressant, antiobsessive-compulsive, and antibulimic actions of citalopram are presumed to be linked to its inhibition of [[CNS]] neuronal uptake of serotonin. [[Iin-vitro]] studies show that citalopram is a potent and selective inhibitor of neuronal serotonin reuptake and has only very weak effects on norepinephrine and dopamine neuronal reuptake. Citalopram has no significant affinity for adrenergic (α1, α2, β), cholinergic, GABA, dopaminergic, histaminergic, serotonergic (5HT1A, 5HT1B, 5HT2), or benzodiazepine receptors; antagonism of such receptors has been hypothesised to be associated with various anticholinergic, [[sedative]], and cardiovascular effects for other psychotropic drugs. The chronic administration of citalopram was found to downregulate brain norepinephrine receptors, as has been observed with other drugs effective in the treatment of major depressive disorder. Citalopram does not inhibit monoamine oxidase <ref name="2a"/>.
 === Pharmacokinetics ===
@@ Line 189: / Line 205: @@
 * increased thirst,
 * irregular heartbeat,
-* lack of energy
+* lack of energy]<
 * lethargy,
 * nosebleed,

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 <references />
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